Peptide Purification By Means of Metal Ion Affinity Chromatography

PROBLEM TO BE SOLVED: To provide an oligopeptide (tag) for purifying an objective protein and a polymer substrate for metal ion affinity chromatography. ; SOLUTION: The polymer substrate is functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group. The cyclic ligand group comprises at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S. The histidine-containing oligopeptide has a specific amino acid sequence. The fusion protein has a protein in which the oligopeptide is fused with the amino terminal or carboxy terminal of an objective protein molecule. ; COPYRIGHT: (C)2009,JPO&INPIT

Patents:
JP 2,009,142,279

Inventor(s): CHRISTENSEN THORKILD; HEARN MILTON THOMAS WILLIAM; SPICCIA LEONE; JIANG WEI; MOONEY JANE THERESE; GRAHAM BIMBIL

Type of Offer: Sale



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