A Nucleotide Vaccine
The present invention relates to a vaccine comprising a nucleic acid construct such as a DNA construct especially a nucleic acid construct comprising sequences encoding invariant chain operatively linked to antigenic protein or peptide encoding sequences. The vaccine stimulates an immune response, especially an immune response in an MHC-I dependent, but CD4<+> T-cell independent manner.
HOLST PETER JOHANNES [DK]; THOMSEN ALLAN RANDRUP [DK]; CHRISTENSEN JAN PRAVSGAARD [DK]
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