Selective Exosite Inhibition of PAPP-A Activity Against IGFBP-4.
The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but not -5. The region comprising LNR3 represents a substrate binding exosite, which can be targeted for selective proteolytic inhibition. Accordingly, the present invention relates in one embodiment to differential inhibition of natural protease substrates by exosite targeting.
MX 2,010,008,083 [MORE INFO
OXVIG CLAUS [DK]; MIKKELSEN JAKOB HAUGE; NIELSEN CLAUS GYRUP
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