Selective Exosite Inhibition of PAPP-A Activity Against IGFBP-4.

The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but not -5. The region comprising LNR3 represents a substrate binding exosite, which can be targeted for selective proteolytic inhibition. Accordingly, the present invention relates in one embodiment to differential inhibition of natural protease substrates by exosite targeting.

Patents:
MX 2,010,008,083   [MORE INFO]

Inventor(s): OXVIG CLAUS [DK]; MIKKELSEN JAKOB HAUGE; NIELSEN CLAUS GYRUP

Type of Offer: Sale



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