Compounds and Methods for the Treatment of Autoimmune and Inflammatory Disease

The present invention provides a method and composition for the treatment and prevention of an autoimmune disease such a multiple sclerosis which is mediated by autoreactive T cells. The administration of a NOD-1 agonist is shown to mediate an anti-inflammatory immune response. NOD-1 agonists suitable for use in the methods and compositions of the invention include diaminopimelic acid (DAP)-containing muropeptide compounds such as Tri-DAP and M-TriDAP.

Attached files:


Patents:
WO 2,010,072,797

Inventor(s): MILLS KINGSTON [IE]; HIGGINS SARAH [IE]

Type of Offer: Sale



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