Intermediates in the Enantioselective Synthesis of 3-(aminomethyl)-5-methyl-hexanoic Acid
(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.
CONNON STEPHEN JOSEPH [IE]; PESCHIULLI ALDO [IT]; MARKEY LYN [IE]
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