A Method for Improving Gene Expression

The present invention is directed to a method for improving gene expression in a host cell comprising a modified protein encoding nucleic acid comprising the steps of assessing the A and T nucleotide content and/or the intrinsic curvature of a wild type protein encoding nucleic acid or mutant thereof, preparing an altered protein encoding nucleic acid with modified A and T nucleotide content and using the altered protein encoding nucleic acid in host cell gene expression systems. The present invention is also directed to the modified nucleic acid sequence, protein, plasmid vector, expression system comprising the altered protein encoding nucleic acid.

Attached files:
WO 2010139797.jpg

Patents:
WO 2,010,139,797

Inventor(s): DORMAN CHARLES [IE]; CORCORAN COLIN [IE]

Type of Offer: Sale



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