Guanidine Based Compounds

The adrenergic receptors or adrenoceptors are a family of G-protein coupled receptors split into a and ss subclasses. The adrenoceptors have important roles in regulating a myriad of physiological conditions and their malfunction has been implicated in the pathophysiology of anumber of diseases. Disclosed herein are a series of novel guanidine and 2-aminoimidazoline compounds which are ligands of the alpha2- adrenoceptor (a2-ARs) subclass of adrenergic receptors. The invention also provides for pharmaceutical compositions comprising the novel compounds. The compounds are suitable for use in the manufacture of medicaments for the treatment of a2-ARs associated disorders, such as depression, schizophrenia, glaucoma and analgesia.

Patents:
WO 9,080,818

Inventor(s): HERNANDEZ MARIA ISABEL ROZAS [IE]; ROYO FERNANDO RODRIGUEZ [ES]; MEANA JAVIER [ES]; CALLADO LUIS [ES]

Type of Offer: Sale



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