A Stimulatable Asymmetrical Polymersome
The invention relates to a polymer vesicle with an asymmetrical unilamellar membrane, said membrane being constituted by two distinct layers, a layer (A) and a layer (B), said layers comprising respective amphiphilic block copolymers with layer (A) comprising, in contrast to said layer (B), an effective quantity of amphiphilic block copolymer comprising at least one stimulatable hydrophobic polymer block, said block polymers provided by said copolymers being capable of adopting a new steric configuration in response to an exogenous stimulus, conditioning the rupture of said unilamellar membrane. The invention also provides a method of producing said vesicle, a method of encapsulating an active ingredient in said vesicles, and a method of controlled release of the active ingredient.
LI MIN-HUI [FR]; MABROUK ELYES [FR]; CUVELIER DAMIEN [FR]; NASSOY PIERRE [FR]; BROCHARD-WYART FRANCOISE [FR]
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