Nucleic Acid Molecules and Methods for Exchanging Exon(s) By Transsplicing
The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre- mRNA) and to mediate a simple or double trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA).
GARCIA LUIS [FR]; LORAIN STEPHANIE [FR]
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