Leptin Antagonists

The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, and fragments of said leptin antagonists.

Patents:
AT 498,683

Inventor(s): GERTLER ARIEH [IL]; CALLEBAUT ISABELLE [FR]; DJIANE JEAN [FR]

Type of Offer: Sale



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