Method for Determining the Susceptibility of a Cell Strain to Drugs
The present invention relates to a method for determining the susceptibility of a cell strain to a compound intended for controlling the growth of said cell strain, comprising: - growing the cell strain in a first compound-free culture medium and in at least a second culture medium comprising the compound at a test concentration; - obtaining mass-spectrometry spectra for a protein extract of the cell strain grown in the first culture medium and for a protein extract of the cell strain grown in the second culture medium; - comparing the mass spectrometry spectra; - deducing that the cell strain is sensitive to the compound at the test concentration if the mass spectrometry spectra are significantly different.
MAZIER DOMINIQUE [FR]; MARINACH-PATRICE CARINE [FR]; ALANIO ALEXANDRE [FR]; GOLMARD JEAN LOUIS [FR]; PALOUS MARTINE [FR]; DATRY
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