Method for Synthesizing Hydroxy-bisphosphonic Acid Derivatives
The present invention relates to a method for preparing a hydroxy-bisphosphonic acid derivative or a salt thereof, from the corresponding carboxylic acid, comprising the following steps: - activation of the carboxylic acid function in the form of the boronate derivative thereof through the action of a borane, then - reaction with tris(trimethyl-silyl)phosphite, under Arbuzov conditions - treatment with an alcohol, chosen in particular from an aliphatic alcohol or trifluoromethanol, and - separation of the hydroxy-bisphosphonic acid derivative formed, from the reaction medium.
EGOROV MAXIM [FR]; FORTUN YANNICK [FR]; HEYMANN DOMINIQUE [FR]; LEBRETON JACQUES [FR]; MATHE MONIQUE [FR]; PADRINES MARC [FR]; R
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