Synthesis of Resorcylic Acid Lactones Useful As Therapeutic Agents.

Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

Attached files:


Patents:
MX 2,010,007,755

Inventor(s): KARPLUS MARTIN [US]; BARLUENGA SOFIA; WINSSINGER NICOLAS

Type of Offer: Sale



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