Biologically Active Compositions, Methods for Producing the Same and Biological Applications

Use of a product from plants comprising extracts, fractions and/or molecules as G-protein coupled receptor (TGR5) specific agonist, having minimum effective concentration (EC50) of greater/equal to TGR5 natural ligand comprising litocholic acid, not activate the farnesoid X receptor (FXR) nuclear receptor, inducing a reduction of weight gain induced by a fatty food to a model, who has metabolic syndrome, and a reduction of mass of fatty cell of epididymis in the models, and inducing a improvement of glucose tolerance, is claimed. Use of a product from plants comprising extracts, fractions and/or molecules as G-protein coupled receptor (TGR5) specific agonist, where the plant extract or fraction is obtained from the extract or the molecules is obtained by the extract or fractions, having minimum effective concentration (EC50) of greater or equal to TGR5 natural ligand, such as litocholic acid, not activate the farnesoid X receptor (FXR) nuclear receptor, inducing a reduction of weight gain induced by a fatty food to a model, who has metabolic syndrome, as well as a reduction of mass of fatty cell of epididymis in the models, and inducing a improvement of glucose tolerance, is claimed. - ACTIVITY : Metabolic; Anorectic; Antidiabetic. - MECHANISM OF ACTION : G-protein coupled receptor agonist. Tests details are described but no results given.

Patents:
EP 2,100,139

Inventor(s): MIOSKOWSKI CHARLES [FR]; LOBSTEIN ANNELISE [FR]; WAGNER ALAIN [FR]; SALADIN REGIS [FR]

Type of Offer: Sale



« More Biotech Patents

---