Single Domain Antibodies Capable of Modulating Bace Activity
The present invention relates to single domain antibodies with a specificity for BACE1. More specifically, the invention provides single variable domain antibodies derived from camelids which bind to BACE1 and are capable of inhibiting the activity of BACE1. Said antibodies can be used for research and medical applications. Specific applications include the use of BACE1 specific antibodies for the treatment of Alzheimer's disease.
DE STROOPER BART [BE]; MARJAUX ELS [BE]; ZHOU LUJIA [BE]; MUYLDERMANS SERGE [BE]
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