Novel Phosphate Modified Nucleosides Useful As Substrates for Polymerases and As Antiviral Angents
This invention provides phosphate-modified nucleosides represented by the structural formula: wherein W is O or S, and wherein B, R1; R3 and R2. are s defined herein. These compounds are useful as substrates for DNA/RNA polymerases, and as anti-viral agents in particular against HIV-1.
HERDEWIJN PIET [BE]; MARLIERE PHILIPPE [FR]
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