Activators of the Autophagic Pathway
By present invention it has been clearly demonstrated that polyamine compounds of the groups consisting of putrescine, spermine, spermidine, cholesteryl spermine, spermidine trihydrochloride, spermidine phosphate hexahydrate, spermidine phosphate hexahydrate and 1,4-butanediamine N-(3-aminopropyl)-monohydrochloride or derivatives thereof or combinations thereof can induce deacetylation or can maintain a condition of hypoacetylation of histone H3 and can activate autophagy and can be used in a treatment to activate or reinstate a normal autophagic pathway.
WINDERICKX JORIS [BE]; EISENBERG TOBIAS [AT]; KROEMER GUIDO [FR]; MADEO FRANK [AT]; MINOIS NADEGE [GB]; ROCKENFELLER PATRICK [AT
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