Aptamers Directed Against the Matrix Protein-1 of Type a Influenza Viruses and Uses Thereof
The present invention relates to nucleic acids that bind specifically to the matrix protein- 1 of type A influenza viruses and uses thereof for detecting such viruses in a sample of interest. More particularly, the present invention relates to a nucleic acid that binds specifically to matrix protein- 1 of type A influenza viruses characterized in that said nucleic acid comprises the following nucleotide sequence: 5'-N1-NS1-U-N3-A-NS3-NS5-NS7-NS6-CGCAU-NS4-C-N4-NS2-N2-3' wherein: - N1 consists of a nucleotide - NS1 and NS2 consist of polynucleotides having 3 or 4 nucleotides in length, and NS1 and NS2 have complementary sequences; - N3 and N4 consists of a nucleotide, and N4 is complementary to N3; - NS3 and NS4 consist of polynucleotides having 3 nucleotides in length, and - NS3 and NS4 have complementary sequences - NS5 and NS6 consist of polynucleotides having 3 nucleotides in length, and - NS5 and NS6 have complementary sequences; - NS7 consists of a polynucleotide selected from the group consisting of AGAAUC (SEQ ID NO:12), UGAG (SEQ ID NO: 13), UAUUCC (SEQ ID NO:14), AGAU (SEQ ID NO:15), AGAATC (SEQ ID NO:16) or TGAG (SEQ ID NO:17) - N2 consists of a nucleotide that is complementary or not complementary to nucleotide N1.
TOULME JEAN-JACQUES [FR]; DAUSSE ERIC [FR]; CORNER FRANCOIS [BE]; DESMECHT DANIEL [BE]
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