Homogeneous, Intrinsic Radiopaque Embolic Particles
The invention is directed to embolic material comprising spherical, homogeneous and substantially non-porous radiopaque polymer particles based on at least one hydrophilic monomer and at least one radiopaque monomer according to general formula wherein R is H, methyl or ethyl, and R1 is I, Br or wherein R2 is O, NH, O-[CH2-CH2-O]p-C(O)-, O-[CH2]m-O-C(O)-, O-[CH2]p-, NH-[CH2-CH2-O]p-C(O)-, NH-[CH2]m-O-C(O)- or NH-[CH2]p- wherein m>1 and p>=1, R3 is I or Br and n is 1, 2 or 3, the iodine and/or bromine content being at least 5 wt. % based on the dry weight of the particle, the said particles having an average particle diameter of at least 10 mum and being able to imbibe water up to a volume increase of the particle of at least 10%.
KOOLE LEVINUS HENDRIK [NL]; VAN HOOY-CORSTJENS CATHARINA S [NL]
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