Method for the Diagnosis of Cystic Fibrosis By Detecting Volatile Organic Compounds in Exhaled Air.
The present invention relates to the identification of markers for the disease conditions related to cystic fibrosis (CF) The uses of such markers in diagnosis and a novel method for their identification are herein described. We were able to discriminate between patients with cystic fibrosis and normal individuals by determining whether the exhaled air contained markers selected from that set. We also found that these markers can be used in the early diagnosis of cystic fibrosis. Moreover, these markers are useful in the prediction of the occurrence of cystic fibrosis even when no other clinical signs are apparent yet. In particular, the marker is selected from the group consisting of 3, 3-dimethylhex-1-ene, 2-buten-1-ol, N-methyl-2-methylpropylamine, C8H16 hydrocarbon (2-octene, 3-octene), tolualdehyde (o-, m-, or p- isomers), C16 poly-unsaturated hydrocarbon, C12 saturated hydrocarbon, C13 saturated hydrocarbon, benzothiazole and long chain alkybenzenes.
DALLINGA JAN WILLEM [NL]; SCHOOTEN VAN FREDERIK JAN [NL]; BERKEL VAN JOEP JOSEPH BENJAMIN NATHAN [NL]
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