Cis Bicyclic Complexes of Platinum (ii) Having Anticancer Activity
The invention relates to compounds having formula (I), wherein: the broken line represents a single or double bond; X is N, O, S, or -(CH2)n-; n is an integer between 1 and 3; R1 is a radical selected independently from among (C1-C4) alkoxyl, phenoxyl, phenyl-(CH2)r-O; R2 and R'2 represent a radical selected independently from among hydrogen, hydroxyl, (C1-C4)-alkoxyl, phenoxyl, phenyl-(CH2)r-O, and O-Gp; r is an integer between 1 and 4; Gp is an alcohol protective group, whereby the radicals with benzene rings are optionally mono-, di- or tri-substituted in the benzene rings thereof with (C1-C4)-alkyl, (C1-C4)-alkoxyl and halogen; R3 and R'3 represent halogen or, taken together, represent a biradical selected from among -OCO-(CH2)m-COO-, (C3-C7)-cycloalkane-1,1-dicarboxylate, and (C3- C7)-cycloalkane-1,2-dicarboxylate; and m is an integer between 0 and 4, which compounds have been shown to be active against different cancer cell lines. Consequently, said compounds are agents that can be used to treat different types of cancer.
MONTANA PEDRERO ANGEL MANUEL [ES]; GAY MARIN MARINA [ES]; SAEZ DIAZ ROSA ISABEL [ES]; DE MIER VINUE JORDI [ES]
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