Spiropiperidyl Rifamycins for the Treatment of Microbacterial Infections

The compounds of formula (1), their pharmaceutically acceptable salts and their solvates, wherein R 1 is a radical selected between hydrogen and alkyl; R 2 is selected from hydroxyalkyl, phenyl, phenyl mono-substituted and phenyl di-substituted in positions 3 and 4; R 3 is selected from phenyl, phenyl mono-substituted and phenyl di-substituted in positions 3 and 4; the substituents of the phenyl of R 2 and R 3 selected from halogen, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxyl and R 4 is selected from hydrogen, alkyl, allyl and homoallyl, they are useful for the treatment of mycobacterial infections, in particular for the treatment of infections produced by Mycobacterium tuberculosis, Mycobacterium avium-intracellulare complex, or Mycobacterium kansasii.

Patents:
ES 2,353,639

Inventor(s): BARLUENGA MUR JOSE; AZNAR GOMEZ FERNANDO; CABAL NAVES MARIA-PAZ; VALDES GOMEZ CARLOS; GARCIA DELGADO ANA-BELEN

Type of Offer: Sale



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