Trangenic mice used as model for human pathologies originating from stem cells
Transgenic non-human mammals that reproduce the human pathology that is of stem cell origin, for example, chromosomal anomalies associated with chronic myeloid leukaemia, B-cell acute lymphoblastic leukaemia, T-cell acute lymphoblastic leukaemia, or with the migration of haematopoietic or embryonic stem calls, using as a strategy the expression of the genes involved in said pathology in human beings by means of a promoter that directs the expression of a transgene in Sca-1<+> cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of useful compounds for the treatment and/or prevention of said diseases.
SANCHEZ GARCIA ISIDRO [ES]; PEREZ LOSADA JESUS [ES]
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