Compositions Comprising Antioxidant and Mitoprotective Flavonoids with Neuroprotective Properties
The present invention discloses compositions comprising phenolic compounds present in plant extracts with therapeutic activity against neuronal excitotoxicity, oxidative stress and mitochondrial dysfunction. When used individually or in a formula composition quercetin, kaempferol and biapigenin significantly reduced neuronal death caused by excitotoxic insults or to exposure to amyloid-beta peptide. Moreover, it is also disclosed that biapigenin interferes with the ANT/mitochondrial transition pore complex contributing for enhanced mitochondrial calcium efflux, thereby reducing calcium burden and contributing for neuroprotection against excitotoxicity.
DIAS ALBERTO CARLOS PIRES [PT]; SILVA BRUNO ALEXANDRE CORDEIRO [PT]; OLIVEIRA PAULO JORGE GOUVEIA S [PT]; MALVA JOAO JOSE OLIVEI
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