Chiral Stationary Phases Based on Xanthone Derivatives
The present invention relates to the development of new chiral stationary phases (CSPs), named chiral xanthone stationary phases (CXSPs), and to the use thereof for the enantiomeric resolution by high-performance liquid chromatography (HPLC). More specifically, it relates to the invention of new xantone-derived chiral stationary phases. The invention relates to the preparation of this type of phases by linking a chiral xanthone derivative (chiral selector) to a spacer that enables subsequently anchoring the chiral selector to a chromatographic support. This new CSP has typical interactions of the Pirkle CSP type and thus possesses all the attributes necessary to achieve chiral recognition and resolution of a variety of enantiomers belonging to various classes of compounds, in various elution modes which involve normal, polar organic and reverse phases.
PINTO MADALENA MARIA DE MAGALHAES [PT]; TIRITAN MARIA ELIZABETH [PT]; FERNANDES CARLA SOFIA GARCIA [PT]; CASS QUEZIA BEZERRA [BR
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