Inhibitors of Receptor Tyrosine Kinases and Methods of Use Thereof.

The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.

Patents:
MX 2,009,013,269

Inventor(s): SCHLESSINGER JOSEPH [US]; LAX IRIT; YUZAWA SATORU; OPATOWSKY YARDEN; YANG YAN

Type of Offer: Sale

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