A Method for Preventing Or Alleviating the Noxious Effects Resulting from Toxicant Exposure

The present invention provides a method of using agents which can modulate TRPAl function as counteragents to inhibit the physical effects of chemical irritants/toxicants when given prior to exposure or to lessen the physical effects when administered post exposure, and more specifically, to a method for counteracting the acute physical noxious effects of toxicants, including but not limited to, tear gases, chlorine, hydrogen peroxide, ammonia, phosgene, chloropicrin, isocyanates and mustard gas. Administering the counteragents counteracts pain, inflammation, lachrymation, blepharospasm, respiratory irritation and depression, airway mucus secretion, airway obstruction and injury, cough and incapacitation and cutaneous chemical injuries.; Another embodiment provides a method of preventing or treating a disease or condition in a mammal, which disease or condition includes hypersensitivity to chemical stimuli, particularly in regards to inflammatory airway conditions, such as asthma, rhinitis, etc., by administering to the mammal a therapeutically effective amount of a compound that inhibits TRPAl function, wherein the compound reduces the hypersensitity and mediates the response to such chemical stimuli in the mammal. The invention also includes a kit containing the compound that inhibits the TRPAl function as a counteracting agent for administration prior to or post exposure to prevent or limit the effects of the exposure.

Patents:
WO 2,009,137,087

Inventor(s): JORDT SVEN-ERIC [US]; BESSAC BRET [US]; SIVULA MICHAEL [US]; BRACKMANN MARIAN [US]

Type of Offer: Sale



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