Conjugate Addition Reactions Using Bifunctional Cinchona-alkaloid-based Catalysts

One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene, comprising the step of: reacting a prochiral electron-deficient alkene with a nucleophile in the presence of a catalyst; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized quinine or quinidine.

WO 2,010,077,607

Inventor(s): DENG LI [US]

Type of Offer: Sale

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