St2-based Dengue Fever Diagnostic

A cytokine receptor family member (ST2), which has membrane bound as well as soluble bound forms, is elevated in patients during acute phase of dengue fever. Moreover, secondary cases of dengue fever had even more pronounced elevation of ST2 in serum in comparison to primary cases. One possible role of soluble ST2 might be to act as decoy for membrane bound ST2 signaling, therefore, promoting a proinflammatory response in secondary dengue infections. Alternatively, ST2 may act as a biomarker for endothelial damage such that ST2 may be useful in identifying severe dengue infections, specifically in dengue hemorrhagic fever.

WO 2,009,145,810


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