Tryptophan As a Functional Replacement for Adp-ribose-arginine in Recombinant Proteins

A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.

Patents:
US 20,090,203,878

Inventor(s): MOSS JOEL [US]; STEVENS LINDA [US]; BOURGEOIS CHRISTELLE [US]; BORTELL RITA [US]

Type of Offer: Sale



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