Tryptophan As a Functional Replacement for Adp-ribose-arginine in Recombinant Proteins
A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
MOSS JOEL [US]; STEVENS LINDA [US]; BOURGEOIS CHRISTELLE [US]; BORTELL RITA [US]
Type of Offer:
« More Biotech Patents