Method for the Solid Phase-based Production of Phosphate-bridged Nucleoside Conjugates

The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perform the immobilization on a solid phase. A subsequent reaction with corresponding nucleophiles results in the desired phosphate-bridged nucleoside conjugates, which can then again be cleaved from the solid phase-bound linker.

Attached files:


Patents:
WO 2,010,127,666

Inventor(s): MEIER CHRIS [DE]; TONN VIKTORIA [DE]

Type of Offer: Sale



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