Label-free Sensing of Pna-dna Complexes Using Nanopores
Embodiments disclosed herein relate to a method of detecting specific DNA sequences and the application of this method in the detection of pathogens, viruses, drug-resistant pathogens, genomic variations associated with disease/disorder susceptibility etc. based on specific signature sequences unique to the pathogens, viruses, drug-resistant pathogens or genomic variations. The method can also be used to distinguish a pool of same-sized dsDNA on the basis of sequence differences. The method uses non-optically labeled bis-PNA and/or gamma-PNA probes to tag specific target sequences for identification by solid-state nanopores.
MELLER AMIT [US]; FRANK-KAMENETSKII MAXIM [US]; WANUNU MENI [US]; KUHN HEIKO [US]; SINGER ALON [US]; MORRISON WILL [US]
Type of Offer:
« More Biotech Patents« More Nanotech Patents