Label-free Sensing of Pna-dna Complexes Using Nanopores

Embodiments disclosed herein relate to a method of detecting specific DNA sequences and the application of this method in the detection of pathogens, viruses, drug-resistant pathogens, genomic variations associated with disease/disorder susceptibility etc. based on specific signature sequences unique to the pathogens, viruses, drug-resistant pathogens or genomic variations. The method can also be used to distinguish a pool of same-sized dsDNA on the basis of sequence differences. The method uses non-optically labeled bis-PNA and/or gamma-PNA probes to tag specific target sequences for identification by solid-state nanopores.

Attached files:
WO 2011028494.jpg

Patents:
WO 2,011,028,494

Inventor(s): MELLER AMIT [US]; FRANK-KAMENETSKII MAXIM [US]; WANUNU MENI [US]; KUHN HEIKO [US]; SINGER ALON [US]; MORRISON WILL [US]

Type of Offer: Licensing



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