Methods and Compositions for Spore-based Vaccines

Methods for immunizing a subject to an infectious agent are provided, using vegetative cytoplasmic expression of an antigen encoding an infectious agent or spore surface display of the antigen, and contacting the subject with a composition including a spore or a vegetative cell or both with or without an adjuvant. Also included are a thermally- stable vaccine composition using the method described above and a kit for its use.

Attached files:


Patents:
WO 2,010,006,326

Inventor(s): HERRMANN JOHN E [US]; BELITSKY BORIS R [US]; SONENSHEIN ABRAHAM L [US]; TZIPORI SAUL [US]

Type of Offer: Licensing



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