Identification of Regulatory T Cells Via the Global Gene Regulator Satb1
The present invention provides a method for the identification of regulatory T cells based on the diminished abundance or even absence of the global gene regulator SATB1 in such regulatory T cells. In particular, the invention relates to a method utilizing ligands that specifically bind to SATB1 for identifying regulatory T cells which are cells showing a reduced binding to said ligand. Such method is suitable for quality determination of a regulatory T cell population. The invention further provides a kit or diagnostic composition for such method.
SCHULTZE JOACHIM LUDWIG [DE]; BEYER MARC DANIEL [DE]; WARNER NOEL [US]; BALDERAS ROBERT [US]
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