Method for Obtaining Human Microglial Precursor Cells from Pluripotent Stem Cells

The present invention relates to a method for obtaining human microglial precursor cells, comprising: (a) providing a ceil population comprising neural precursor cells, wherein the cell population is obtainable from embryoid bodies differentiated from human pluripotent stem cells; (b) differentiating the cell population comprising neural precursor cells into microglial precursor cells by culturing in medium comprising a growth factor selected from the group consisting of insulin and insulin-like growth factors; (c) expanding and enriching microglial precursor cells in medium comprising a growth factor selected from the group consisting of insulin and insulin-iike growth factors and 10 to 150 ng/ml GM-CSF; and (d) isolating microglial precursor cells comprising CD45-positive cells.

Patents:
WO 2,010,125,110

Inventor(s): NEUMANN HARALD [DE]; ROY KRISTIN [DE]; BRUESTLE OLIVER [DE]; PEITZ MICHAEL [DE]

Type of Offer: Sale



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