Modified Cipa Gene from Clostridium Thermocellum for Enhanced Genetic Stability

Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic stability. This mutated cipA gene can be introduced into a heterologous host, such as Thermoanaerobacterium saccharolyticum. Other cellulosome components may be introduced into the host to build a full-sized cellulosome in T. saccharolyticum. Manipulation of the scaffoldin genes provides a new approach for enhancing ethanol production by biomass-fermenting microorganisms.

Patents:
WO 2,010,124,000

Inventor(s): CURRIE DEVIN HEDLEY [US]; MCBRIDE JOHN [US]; GUSS ADAM [US]

Type of Offer: Licensing



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