Female Reproductive Tract and Anal Prophylaxes

The present invention provides methods for boosting mucosal immunity in the female reproductive tract of pre- and post -menopausal women using a TGF-beta inhibitor, a Selective Estrogen Receptor Modulator, and/or a recombinant commensal bacterium that expresses endogenous microbicides into the intestinal tract or reproductive tract of a subject. It also provides methods for boosting innate and adaptive immunity by providing a glucocorticoid. Methods for preventing sexually transmitted infections including HIV infection are also provided.

Attached files:


Patents:
WO 2,009,143,309

Inventor(s): WIRA CHARLES R [US]; FAHEY JOHN V [US]; SENTMAN CHARLES L [US]; GUYRE PAUL M

Type of Offer: Licensing



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