Self-assembling Micelle-like Nanoparticles for Systemic Gene Delivery.

Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA- containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid/PEG- lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor.

Attached files:
MX 2010005089.jpg

Patents:
MX 2,010,005,089

Inventor(s): KO YOUNG TAG [US]; KALE AMIT; TORCHILIN VLADIMIR P

Type of Offer: Licensing



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