Iap Binding Compounds
Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these compounds for therapeutic, diagnostic and assay purposes.
SHI YIGONG [US]; SEMMELHACK MARTIN F [US]; CASE MARTIN [US]; ALBINIAK PHILIP A [US]; MCLENDON GEORGE [US]; KIPP RACHAEL A [US];
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