Demethylation and Inactivation of Protein Phosphatase 2a

Embodiments of the present invention relate to atomic coordinates for PME-1 alone or in complex with PP2A, as well as methods for using these atomic coordinates to prepare inhibitors of PME-1 and/or PP2A and inhibitors prepared using such methods. Further embodiments relate to biochemical analyses of the interactions of PME-1 alone or in complex with PP2A. Further embodiments relate to compositions including mimetics and small molecules, optionally, secondary agents, which may be used to treat disorders in which PME-1 and/or PP2A activity plays a contributing role.

Attached files:


Patents:
WO 2,009,100,173

Inventor(s): SHI YIGONG [US]; XING YONGNA [US]

Type of Offer: Licensing



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