Strategy for Homo- Or Hetero-dimerization of Various Proteins in Solution and in Cell

The present invention describes a chimeric polypeptide comprising a first portion comprising a receptor domain, wherein the receptor domain comprises an intracellular region and a transmembrane region; and a second portion comprising a dimerization domain. The present invention also describes a chimeric polypeptide comprising a first portion comprising a receptor domain, wherein the receptor domain comprises a receptor extracellular region; and a second portion comprising a dimerization domain, wherein the dimerization domain comprises an antibody heavy chain region of a Fab fragment or an antibody light chain region. Polynucleotides encoding the chimeric polypeptides and methods of use of the chimeric polypeptides are also described.

Attached files:
US 20110038854.jpg

Patents:
US 20,110,038,854

Inventor(s): KOTENKO SERGEI V [US]

Type of Offer: Licensing



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