Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
A method of sorting mixtures of nucleic acid strands comprising hybridizing the strands to an array of immobilized oligonucleotides, each of which includes a constant segment adjacent to a variable segment. The constant segment of the immobilized oligonucleotides can be made complementary to the ends of strands obtained by digesting a double-stranded nucleic acid with a restriction enzyme and restoring the restriction sites, thereby permitting the sorting of strands according to their variable sequences adjacent to their constant terminal restored restriction sites.
CHETVERIN ALEXANDER B [RU]; KRAMER FRED RUSSELL [US]
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