Synthesis of Cyclic Diguanosine Monophosphate and Thiophosphate Analogs Thereof
The invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series of seven phosphorothioate derivatives that includes diastereomers of mono-, di-, and trithiophosphates.
JONES ROGER A [US]; GAFFNEY BARBARA L [US]
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