Method for Determining the Quality of Heparin

The invention relates to a method for determining contamination of heparin with other sulfated glycans, comprising the steps: incubating a predetermined amount of heparin together with a predetermined amount of an enzyme that specifically digests heparin for a predetermined duration, wherein the amount of the enzyme corresponds approximately to the amount of the enzyme that would completely degrade an approximately identical amount of contaminant-free heparin within the predetermined duration, or is greater; incubating the digested heparin together with an indicator molecule that changes the fluorescence properties thereof in the presence of sulfated glycans, detecting the fluorescence of the digested heparin incubated together with the indicator molecule, wherein fluorescence indicating the presence of a sulfated glycan indicates the presence of contaminants.

Patents:
WO 2,011,026,450

Inventor(s): ALBAN SUSANNE [DE]; LUEHN SUSANNE [DE]; SCHIEMANN SIMONE [DE]

Type of Offer: Sale



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