Non-cytotoxic PAP mutants
Disclosed are PAP mutants that are less toxic than wild type PAP and that exhibit depurination activity. Also disclosed are transgenic plants that produce the PAP mutants, and methods for preparing the plants. Further disclosed are bioconjugates containing the PAP mutants, pharmaceutical compositions containing the bioconjugates, and methods of administering the compositions to treat disease.
TUMER NILGUN E [US]; HUDAK KATALIN A [US]; PARIKH BIJAL [US]
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