Detection of Prostate Cancer Using Psa Glycosylation Patterns
The present invention features novel methods for determining if a subject has prostate cancer. The present invention is based on the development of lectin immunosorbant assays which analyze [alpha]2,6-linked sialylation of total serum PSA by sambucus nigra lectin (SNA) and [alpha]2,3-linked sialylation of total and free serum PSA. These novel assays were used then to conduct a clinical investigation of the potential role of glycoprotein analysis in improving PSA's cancer specificity. The present invention also features kits for determining if a subject has prostate cancer comprising one or more lectins and a PSA specific antibody and instructions for use.
ZHANG HUI [US]; MEANY DANNI LI [US]; CHAN DANIEL W [US]; ZHANG ZHEN [US]; LI YAN [US]; SOKOLL LORI J [US]
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