Novel Compunds, Pharmaceutical Compositions Containing Same, and Methods of Use for Same

A pharmaceutical composition comprising a phamaceurtical diluent and a compound of formula IV wherein R21= H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, -CH2OR25, -C(O)R25, -CO(O)R25, -C(O)NR25R26, -CH2C(O)R25, or ûCH2C(O)NHR25, where R25 and R26 are each independently H, C1-C10 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R22= -OH, -OR27, -OCH2C(O)R27, -OCH2C(O)NHR27, -OC(O)R27, - OC(O)OR27, -OC(O)NHNH-R5, or -OC(O)NR27R28, where R27 and R28 are each independently H, C1ûC20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where R27 and R28 can each optionally contain halogen atoms; R23 and R24, the same or different from each other, are C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially- based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1. (no suitable figure)

Attached files:
SG 169236.jpg

Patents:
SG 169,236

Inventor(s): KUHAJDA FRANCIS P; MEDGHALCHI SUSAN M; MCFADDEN JILL M; THUPARI JAGAN; TOWNSEND CRAIG A

Type of Offer: Licensing



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