Methods for Enhancing Antigen-specific Immune Responses

Methods for delivering naked DNA vaccines to enhance immune responses, by improving transfection efficiency without safety concerns associated with live viral vectors, are described. A method may comprise administering to a mammalian subject an effective amount of a papillomavirus pseudovirion, wherein the papillomavirus pseudovirion comprises at least one papillomavirus capsid protein encapsidating a naked DNA vaccine, wherein the naked DNA vaccine comprises a first nucleic acid encoding at least one antigen, thereby enhancing the antigen specific immune response relative to administration of the naked DNA vaccine.

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Patents:
WO 2,011,017,162

Inventor(s): WU TZYY-CHOOU [US]; HUNG CHIEN-FU [US]; RODEN RICHARD [US]

Type of Offer: Licensing



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